SigTuple

Automate microscopic analysis of blood and urine samples with AI-powered digital cell morphology.

Combines AI, robotics, and high-resolution microscopy to assist pathologists and clinicians in making timely, accurate decisions.

Best forAutomating blood and urine microscopy in clinical labs.

DifferentiatorIntegrated hardware/software platform with on-device AI and FDA/CE clearance.

Proof350+ deployments, 27 patents, FDA + CE clearance.

Explore SigTuple

Pricing on request

8.9 Zekai

Automated Digital Microscopy

AI for Doctors & Medical

Ease of Use

8.2

Accuracy

9.5

Value

8.5

Time Saving

9.2

350+Users

8.9/10Zekai Score

AI DiagnosticsDigital PathologyRemote CollaborationFDA ClearedCE Compliant

📊 Independently tested and scored. How we score →

✍️ Reviewed by Zekai Editorial Team · Updated August 7, 2026

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⚡ Quick answer

For Doctors & Physicians, SigTuple is a leading AI for automating diagnostic pathology. It provides FDA and CE-cleared hardware platforms that use AI to automatically analyze peripheral blood smears and urine sediment, significantly reducing manual review time. With over 350 deployments, it's proven to increase diagnostic speed and accuracy, especially in resource-limited settings.

CategoryAI Diagnostic Pathology

Best ForAutomating blood and urine microscopy in clinical labs.

Price FromPricing on request

FreeNo

DifferentiatorIntegrated hardware/software platform with on-device AI and FDA/CE clearance.

Proof350+ deployments, 27 patents, FDA + CE clearance.

Rating4.5/5

📖 About SigTuple

SigTuple provides AI-powered diagnostic platforms that automate the microscopic analysis of biological samples. For physicians and pathologists, it streamlines the review of peripheral blood smears and urine sediment, enabling faster, more consistent, and accurate diagnoses.

How It Works

Your workflow, automated

Load Sample

Place peripheral blood or urine slides into the SigTuple automated scanner.

Automated Scan & AI Analysis

The device digitizes the slide at high resolution and AI identifies and classifies cells on-device or via cloud.

Review & Report

Pathologists review the AI-flagged findings remotely via a browser, confirm the diagnosis, and release the report.

Ready to automate your workflow with SigTuple?

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Real Impact

Before & After

❌ Before

Manual, slow, and inconsistent microscopic slide reviews.

Hours-long turnaround times

✅ After

Automated, standardized, and rapid analysis of blood and urine.

Minutes-to-results for screening

Prompt Templates

Try it with these prompts

Copy any prompt and paste it directly into the tool.

Analyze blood smear for leukocyte differential

Analyze a peripheral blood smear to provide a leukocyte differential count. The analysis should identify and quantify different types of white blood cells, such as neutrophils, lymphocytes, monocytes, eosinophils, and ba…

Automated urine sediment analysis

Perform an automated analysis of urine sediment to identify and quantify various cellular and non-cellular components. This includes red blood cells, white blood cells, epithelial cells, casts, crystals, and bacteria, pr…

Veterinary blood sample analysis

Analyze veterinary blood samples for diagnostic purposes, integrating microscopy, microfluidics, and intelligent workflows. The system should deliver reliable results for a range of biological samples commonly found in v…

Social Proof

Trusted by 350+

350+ professionals using this tool

Ease of Use

8.2

Accuracy

9.5

Value

8.5

Time Saving

9.2

"Implementing the AS76 has transformed our lab's throughput. The automated leukocyte differential is incredibly accurate and has freed up my team to focus on complex and borderline cases."

Anjali K., Head of Pathology · June 2026

"The ability to digitize our slides and enable remote review has been a game-changer for collaboration with our consulting hematologists. The image quality is superb."

David L., Lab Director · May 2026

"A powerful platform for hematology, no question. However, the initial capital outlay was significant, and I wish it covered a broader range of pathology tests beyond blood and urine."

Mei R., Chief Medical Officer · April 2026

"We deployed the AI100 in our rural clinic, and it has fundamentally improved our diagnostic capabilities. We're getting reliable results in hours, not days."

Samuel B., Clinician · March 2026

350+ professionals are already using this tool.

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Connects With

Works with your existing stack

HORIBA

Setup complexity: Specialist Hardware

Comparison

How it compares

SigTuple provides a complete, integrated hardware and AI software solution for hematology and urinalysis, making it ideal for labs needing an end-to-end automated microscopy system with FDA/CE clearance. In contrast, a platform like PathAI focuses more broadly on software that integrates with various third-party scanners and digital pathology workflows across different tissue types. Choose SigTuple when you need a purpose-built, all-in-one device for blood and urine. Opt for a software-centric solution if you have existing digital scanners and require a more flexible platform for diverse pathology needs.

The decision

Is it worth it?

Return on investment

By automating manual microscopy, which can take over 20 minutes per slide according to WHO guidelines, labs using SigTuple can process samples in minutes, potentially saving hundreds of pathologist hours per month.

Built for

Pathologists, clinicians, and laboratory professionals in hospital laboratories, independent diagnostic centers, and reference labs.

Effort to adopt

Specialist Hardware

Compliance

Platforms are CE-IVDR Compliant and FDA Cleared. The AS76 model features on-device AI for enhanced data privacy, with no cloud dependency.

Who It's For

Why Doctors & Medical choose this tool

🎯

Built for

Best for pathologists and clinical laboratories seeking to automate and scale microscopic analysis of blood and urine samples for faster, more consistent diagnostics.

In-Depth Overview

For physicians and pathologists, SigTuple moves microscopic analysis from a manual, time-consuming task to an automated, efficient workflow. Its platforms combine AI, robotics, and high-resolution microscopy to analyze biological samples with pathologist-grade accuracy. The AS76 platform, designed for larger labs, is CE-IVDR compliant and uses true 100X oil immersion to scan six slides at once, with all AI models running on the device for complete data privacy. The AI100, for small to medium labs, is both FDA and CE cleared, analyzing peripheral blood smears and urine sediment. Proof of its effectiveness is extensive: the company holds 27 patents, has over 30 publications, and has completed over 350 deployments in 7 countries. Real-world case studies show its impact in detecting leukemia in rural India where pathologists are scarce. By automating the identification of over 30 cell types and enabling browser-based remote review, SigTuple allows clinicians to focus their expertise on critical cases, increasing throughput and standardizing diagnostic quality across institutions like HCG Hospitals and Krsnaa Diagnostics.

Key Use Cases

🔬

Accelerate Blood Smear Reviews

Pathologist

Use the AS76 platform to automatically scan 6 slides simultaneously, with an AI-powered 200-cell leukocyte differential. Focus your expertise on abnormal cases flagged by the system.

Reduced manual review time

💼

Scale Diagnostic Capacity

Lab Manager

Implement SigTuple to manage increasing sample volumes without a proportional increase in staff. Standardize analysis across the lab to ensure consistent quality and faster reporting.

Higher sample throughput

🏥

Access Specialist-Level Diagnostics

Rural Clinician

Deploy the AI100 system to perform automated blood and urine analysis on-site, sharing complex cases with remote pathologists for expert consultation and timely diagnosis.

Faster diagnosis in remote areas

✓ Pros

FDA and CE cleared platforms provide regulatory confidence.

Combines hardware and AI for a complete automated workflow.

On-device AI processing option (AS76) ensures data privacy and speed.

Enables remote review and specialist collaboration by digitizing slides.

Proven to improve diagnostic access in resource-limited settings.

· Cons

Requires significant capital investment in physical hardware.

Pricing is not transparent and requires a sales consultation.

Primarily focused on hematology and urinalysis, not all pathology types.

The AI100 model relies on the cloud, which may not suit all security policies.

⚡ Editorial Verdict

SigTuple is a powerful, hardware-based solution for automating hematology and urinalysis microscopy, backed by FDA/CE clearance and extensive real-world deployments. Its on-device AI offers privacy and speed, but the requirement for physical hardware makes it a significant capital investment compared to software-only solutions.

See all Doctors & Medical AI tools → Browse the AI Directory →

Questions & Answers

Frequently asked questions

What is AI-powered microscopy?

AI-powered microscopy combines digital imaging with artificial intelligence to assist in the analysis of microscopic samples. AI helps identify, classify, and prioritize findings, enabling laboratories to review samples more efficiently and consistently.

How does digital pathology work?

Digital pathology transforms traditional glass slides into high-resolution digital images that can be viewed, analyzed, and shared electronically. This streamlines collaboration, supports remote consultations, and creates opportunities for AI-assisted analysis.

Can digital pathology enable remote review?

Yes. One of the key advantages of digital pathology is the ability to securely access and review digital slides from virtually anywhere. This enables remote pathology review, making it easier for laboratories to collaborate with specialists and obtain second opinions.

How does SigTuple improve laboratory workflows?

SigTuple improves laboratory workflows by automating time-consuming review steps, assisting with morphology analysis, and providing decision support. By reducing manual effort and standardizing reviews, it enables teams to process samples more efficiently and focus their expertise where it matters most.

Which laboratories can use SigTuple platforms?

SigTuple platforms are designed for a wide range of diagnostic environments, including independent laboratories, hospital laboratories, pathology centers, reference laboratories, and veterinary diagnostic facilities.

Does SigTuple offer on-premise AI to ensure patient data privacy?

Yes, the AS76 model runs all AI analysis on the device with no cloud dependency for complete data privacy. The AI100 platform utilizes the cloud for AI-aided remote review and unlimited scan storage.

Last reviewed: June 2026 — Assessed AI-powered hardware platforms for blood and urine analysis.

Plans & Pricing

Start today

Pro

Pricing on request

Requires a demo and direct sales consultation. Pricing is for a hardware and software platform.

Start Pro Plan

Prices and features are updated regularly but can change at any time — always confirm on the official website. Some links on this page are affiliate links.

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SigTuple Alternatives (2026)

The best alternatives to SigTuple — every tool below is tested and scored by Zekai.

Compare	SigTuple	Notable	Syllable AI
Zekai Score	8.9/10	9.5/10	9.5/10
Rating	4.5/5	4.7/5	4.7/5
Pricing	Pricing on request	—	Metered Pay-As-You-Go: Start with a $150 prepayment. Auto-recharges $100 when your balance drops below $50.
Free tier	No	No	Yes
Best for	Best for pathologists and clinical laboratories se…	Health systems and medical groups looking to scale…	Health systems and medical groups seeking an EHR-i…

Notable Syllable AI Biofourmis OpenEvidence Kry (Livi)Corti AI Merative Nabla Copilot

Free guide

Take it with you

Getting Started with AI-Powered Microscopy

Understanding the shift from manual to digital pathology.
Key benefits: speed, consistency, and remote access.
Core components of an AI microscopy system: scanner, AI software, viewer.

Evaluating on-device vs. cloud-based AI processing.
Regulatory considerations: Why FDA and CE clearance matters.

+4 more steps inside the guide

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Disclaimer

Zekai is an independent AI tools directory. We are not affiliated with, endorsed by, or officially connected to SigTuple unless clearly stated. All product names, logos, and brands are the property of their respective owners and are used for identification purposes only. The information on this page — including pricing, features, and availability — is general information, may have changed since our last review, and is not professional advice. Zekai Scores and verdicts are our editorial opinion. Some outbound links are affiliate links that may earn us a commission at no extra cost to you. Spotted outdated or incorrect information? Request a correction →

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SigTuple

Top AI for Doctors & Medical picks

Your workflow, automated

Before & After

Try it with these prompts

Trusted by 350+

Works with your existing stack

How it compares

Is it worth it?